Six year follow up of children at high hereditary risk of allergy born to mothers participating in the DOMInO Trial.

INTERVENTION: This study is a follow up children born to women participating in the DOMInO Trial: ACTRN12605000569606. Women were asked to consume 3 x 500mg DHA rich Tuna Oil capsules daily from 18‐21 weeks gestation until birth of child. CONDITION: Atopy & Allergic Disease PRIMARY OUTCOME: Incidence of allergic disease symptoms (eczema, allergic rhinitis or wheeze) with sensitisation (determined by a positive skin prick test to food allergens or aeroallergens) in the child. SECONDARY OUTCOME: Symptoms of individual allergic disease (eczema, allergic rhinitis or wheeze) with or without sensitisation in the child at 6 years of age. Sensitisation to individual allergen extracts. INCLUSION CRITERIA: Child was consented to nested 1 and 3 year allergy cohort of the DOMInO trial prior to birth with family history of medically diagnosed allergic disease (eczema, asthma, allergic rhinitis): Women in DOMInO trial had singleton pregnancy less than 18‐21 weeks gestation with no known fetal abnormality: mothers not to have had documented history of alcohol or drug abuse: no participation in other clinical trials with fatty acid