Effect of St. John`s wort on the pharmacokinetics and pharmacodynamics of oral oxycodone: A two-phase double-blind cross-over study in healthy volunteers /Mäkikuisman vaikutus suun kautta annetun oksikodonin farmakokinetiikkaan ja dynamiikkaan: kaksivaiheinen kaksoissokea vaihtovuoroinen tutkimus terveillä koehenkilöillä

INTERVENTION: Trade Name: Oxynorm Product Name: Oxynorm Pharmaceutical Form: Capsule* INN or Proposed INN: OXYCODONE HYDROCHLORIDE CAS Number: 124903 Concentration unit: mg milligram(s) Trade Name: Jarsin® 300 mg Product Name: Jarsin ® 300 mg Pharmaceutical Form: Tablet INN or Proposed INN: St John`s plant Concentration unit: mg milligram(s) Concentration type: up to Concentration number: 300‐ Pharmaceutical form of the placebo: Capsule, soft Route of administration of the placebo: Oral use CONDITION: Drug interaction study PRIMARY OUTCOME: Main Objective: Interaction study Primary end point(s): 48 h from test medication Secondary Objective: INCLUSION CRITERIA: Healthy, 18‐40 years, nonsmoking, without chronic diseases or medication Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) F.1.3.1 Number of subjects for this age range