A Randomized Controlled Trial Comparing the Diagnostic Yield of using Rapid On-Site Cytology Evaluation (ROSE) and without using ROSE in Radial Probe Endobronchial Ultrasound (R-EBUS) Guided Sheath Transbronchial Lung Biopsy with Bronchial Brushing in Peripheral Pulmonary Lesions

INTERVENTION: Experimental Procedure/Surgery,No Intervention Procedure/Surgery Once the target site was located, bronchial brushing was done, then cytologist evaluate a cytology by using ROSE.the next step is transbronchial biopsy immediately.Once it has been done 3 times, whether abnormal cells are found or not found, the next step is biopsy.,Once the target site was located, bronchial brushing was done for 3 times without ROSE, then the next step will be transbronchial biopsy immediately, where 5 biopsies will be performed. RPEBUS with bronchial brushing with ROSE,RPEBUS with bronchial brushing CONDITION: All patients over the age of 18 who have been scheduled for bronchoscope to get the tissue diagnosis from the peripheral lung lesions at the pulmonary unit, Chulalongkorn Hospital ; Rapid on‐site cytology evaluation (ROSE), Radial Probe endobronchial ultrasound (RP‐EBUS), Transbronchial lung biopsy, Peripheral pulmonary lung lesion, Bronchial brushing, Bronchus sign Rapid on‐site cytology evaluation (ROSE), Radial Probe endobronchial ultrasound (RP‐EBUS), Transbronchial lung biopsy, Peripheral pulmonary lung lesion, Bronchial brushing, Bronchus sign PRIMARY OUTCOME: diagnosis yield of peripheral lung lesions or nodules from the use of rapid on‐site cytological evaluation (ROSE) during REBUS transbronchial biopsy and brushing in versus the control group. immediately after procedure diagnostic yield of peripheral lung lesion SECONDARY OUTCOME: duration of RP‐EBUS, sedative doses, amounts of blood loss of RP‐EBUS transbronchial biopsy and brushing in peripheral lung lesions between ROSE group versus control groups. immediate after procedure duration of procedure time, sedative dose, amount blood loss INCLUSION CRITERIA: 1. All patients over 18 years old 2.All patients diagnosed with peripheral lung lesions or nodule size smaller than or equal to 3 centimeters from chest computed tomography.