Is dexamethasone as effective as other corticosteroids for acute asthma exacerbation in children?

Category Broad synthesis / Living FRISBEE
Year 2017
Dexamethasone has been proposed as an alternative in the treatment of acute asthma exacerbation in children. It allows shortening the duration of treatment, reducing costs and adverse effects. However, it is not clear whether its efficacy is similar to the traditional steroid regimen. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple information sources. We identified six systematic reviews including 10 randomized trials. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We concluded dexamethasone has probably fewer adverse effects than others corticosteroids, and might be equally effective in reducing hospitalizations and revisits.
Epistemonikos ID: c321f165a9c0dd85062ba655d76bb4ef8483d24b
First added on: Jul 31, 2017