Clinical significance of oxidative stress evaluation in gastrointestinal cancer diagnosis

Aim: To analyze oxidative stress in patients with gastrointestinal tumors. Methods: Two hundred patients with gastrointestinal cancer treated from September 2011 to September 2013 at our hospital were randomly selected and divided into a gastric cancer group (n = 100) and a colorectal cancer group (n = 100). Fifty healthy volunteers receiving physical examination during the same period at our hospital were used as controls. All study subjects were subjected to measurement of serum oxidative damage products, antioxidants and antioxidant enzymes. Results: The concentrations of protein carbonyl (PC), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and 8-hydroxy- 2'-deoxyguanosine (8-OHdG) in patients with gastric cancer and colorectal cancer were significantly different from those in healthy controls (4.12 nmol/L ± 1.34 nmol/L, 4.24 nmol/L ± 1.29 nmol/L vs 2.83 nmol/L ± 0.71 nmol/L; 31.93 μmol/L ± 12.34 μmol/L, 32.14 μmol/L ± 11.69 μmol/L vs 25.91 μmol/L ± 9.10 μmol/L; 2.98 nmol/L ± 1.13 nmol/L, 3.02 nmol/L ± 1.24 nmol/L vs 6.13 nmol/L ± 1.82 nmol/L; 125.91 mg/L ± 5.00 mg/L, 124.13 mg/L ± 5.00 mg/L vs 96.16 mg/L ± 68.29 mg/L, P < 0.05), although there were no significant differences between the gastric cancer and colorectal cancer groups (P > 0.05). The concentrations of glutathione, glutathione (GSH), vitamin C and vitamin E in patients with gastric cancer and colorectal cancer were significantly different from those in healthy controls (P < 0.05), although there were no significant differences between the gastric cancer and colorectal cancer groups (P > 0.05). Superoxide dismutase (SOD), glutathione peroxide matter enzyme (GSH-Px) and catalane (CAT) activity in patients with gastric cancer and colorectal cancer were significantly different from those in healthy controls (P < 0.05), although there were no significant differences between the gastric cancer and colorectal cancer groups (P > 0.05). Conclusion: Patients with gastrointestinal tumors undergo oxidative stress, and evaluation of oxidative stress in patients with gastrointestinal cancer has important clinical significance in determining the occurrence of gastrointestinal cancer.