The efficacy and safety of Kampo (Japanese herbal) medicines, maoto and maotokasekko, in treatment of influenza virus infections

INTERVENTION: administration of maoto consumption of 2 packs of maoto directly after the consultation, subsequent application of 2 packs after 4 and 8 hours and 1 pack after 16, 24, and 32 hours, respectively administration of maotokasekko consumption of 2 packs of maotokasekko directly after the consultation, subsequent application of 2 packs after 4 and 8 hours and 1 pack after 16, 24, and 32 hours, respectively administration of oseltamivir (Tamiflu) consumption of 1 capsule of Tamiflu 2 times a day, in the morning and the evening, for 5 days CONDITION: influenza virus infections PRIMARY OUTCOME: time to the alleviation of all major symptoms; definition of "alleviation of all major symptoms"; 1. without sensation of heat; 2. oral temperature is 37.8 degree C or lower; 3. disappearance or mild state of all the symptoms below; 1. sore throat; 2. cough; 3. muscle pain; 4. headache; 4. above state is kept more than 24 hours SECONDARY OUTCOME: time to the absence of fever; time to the alleviation of individual symptoms; time to the resumption of normal activities; adverse drug events INCLUSION CRITERIA: patients with influenza virus infection who meet all the requirements below 1. oral temperature equal or higher than 37.8 degree C 2. two or more symptoms shown below headache muscle pain cough sore throat 3. within the first 36 hours after the onset of symptoms 4. identification of influenza virus by PCR methods