Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Solid Tumors

Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2015
The purpose of this phase I study is to test the safety of different dose levels of specially prepared cells collected called \"modified T cells\". In the screening part of this study the tumor was found to have a protein called MUC16. This protein is present on about 70% of ovarian cancers. The investigators want to find a safe dose of modified T cells for patients with this type of cancer that has progressed after standard chemotherapy. We also want to find out what effects these modified T cells have on the patient and their cancer.
Epistemonikos ID: c061aff221e20635c2bad1bb5fdb8b34e904bf71
First added on: May 12, 2024