Study of Artemether-lumefantrine, Amodiaquine and Primaquine in Healthy Subjects

Primary Objective * To characterize the potential pharmacokinetic interactions of artemether -lumefantrine, amodiaquine and primaquine in healthy adult subjects. Secondary Objectives * To characterize the pharmacokinetic properties of artemether-lumefantrine, amodiaquine and primaquine when given alone and in combination. * To evaluate the safety and tolerability of co-administered artemether-lumefantrine, amodiaquine and primaquine. * To investigate pharmacogenetic polymorphisms affecting drug levels of artemether-lumefantrine, amodiaquine and primaquine and their metabolites.