N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2015
Recent data have suggested that monocyte oxidative burst defect is associated with the development of infection in patients with severe alcoholic hepatitis. One report found reduced 28 day mortality in patients treated with N-acetylcysteine combined with prednisolone when compared to prednisolone alone. The current study seeks to reveal whether the mechanism by which NAC reduces susceptibility to infection is through improvement of phagocyte oxidative burst.
Epistemonikos ID: be95e3dae5ab62b61cca887994d920d63c9daed7
First added on: May 20, 2024