In the blood sample of the patients planned for nasal septoplasty was evaluated the level of opioid analgesic receptor and the relations between the level of receptor and pain score,

INTERVENTION: All patients were randomly selected to have into two groups. For postoperative analgesia, the first group (n=60) is patients using tramadol (1‐2 mgr/ kg, intravenously) at the end of the surgery for postoperative analgesia. It is single dose. The second group is control group, and patients are initially given only fentanyl in the induction for analgesia. Fentanyl (1 µg/ kg, intravenously), propofol (2‐3 mgr/ kg, intravenously), and muscle relaxant (rocuronium bromide 0,6 mgr/ kg, intravenously) are administered to all patients for induction as single dose. The medications were given intravenously to each group before awakened were performed by the Anesthesia Care Team. All the patients’ vital signs were monitored during the operation. We planned to audit of anesthesia nurse notes to assess or monitor fidelity to the intervention. CONDITION: Anaesthesiology ‐ Pain management patients undergoing septoplasty operation; ; patients undergoing septoplasty operation PRIMARY OUTCOME: A continuous 10 cm visual analog scale (VAS) score was used to determine the level of postoperative pain. On the scale, 0 indicated ‘no pain’, and 10 indicated ‘severe pain’. The patients were asked to mark their pain at different times on the scale, and the results were calculated and recorded in millimeters. [Timepoints were the 1st (primary timepoint), 3rd, 7th and 10th hours in postoperative period.] SECONDARY OUTCOME: needed second analgesic agent (Acetaminophen with codeine analgesic 325/ 30 mg. per‐oral) timing and amount was recorded in postoperative period. We obtained this data from hospital nurse or physician records.[immediately in postoperative recovery room.] INCLUSION CRITERIA: Patients undergoing septoplasty