Intradialytic protein ingestion and exercise study

INTERVENTION: During four hemodialysis sessions, patients will (A) ingest a placebo drink, (B) ingest a placebo drink and perform aerobic exercise, (C) ingest a protein supplement, and (D) ingest a protein supplement and perform aerobic exercise. CONDITION: Hemodialysis, Protein, Amino acids, Physical exercise ; ; PRIMARY OUTCOME: Primary study parameters are amino acid loss into the dialysate and plasma total amino acid concentrations. SECONDARY OUTCOME: Secondary study parameters are the loss of essential amino acids into the dialysate, plasma essential amino acid, glucose, and insulin concentrations, interstitial glucose concentrations, and changes in blood pressure. INCLUSION CRITERIA: ‐ Aged >18 years ‐ Ability to provide written informed consent ‐ Hemodialysis treatment for >3 months ‐ Well‐functioning arteriovenous shunt in upper or lower arm