Functional Magnetic Resonance Imaging (fMRI) investigation of Laser Acupuncture on Acupoints useful in Mild to Moderate Depression : Healthy Subjects.

INTERVENTION: 1. Laser acupuncture on acupoints right LR14 ( 6th intercostal space midclavicular line), CV14 ( epigastrium 10 cm below the xiphisternum), HT7 at medial left wrist and LR8 at left medial knee region at junction of semitendinosus and semimembranosus muscles. 2. Interventions all in a single session. 3. Laser continuous beam 804nm, 25 mW output, each block of laser 20 seconds, total laser time 160seconds in the session. 4. Total time per session 30mins. 4. Block design laser‐rest or sham‐laser‐ rest or sham ( LRLR) with 9 rests and 8 active lasers to each acupoint. CONDITION: Mild to moderate depression PRIMARY OUTCOME: Brain positive and negative activations with functional magnetic imaging (fMRI) from active laser to each acupoint using statistical parametric mapping (SPM) analysis. SECONDARY OUTCOME: Brain positive and negative activations with functional magnetic imaging (fMRI) from sham laser to each acupoint using statistical parametric mapping (SPM) analysis. INCLUSION CRITERIA: 1. Healthy subject 2. Right handed 3. Able to undergo magnetic resonance imaging scan. 4. Able to provide informed consent.