Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis.

The requested reference [15f2a2ca40d6f2fd3b484ab7ee1e4d28b316d162] no longer exists in our database. It has been replaced by the current reference: [f2629013bfbec5104b02f52a4ed7b3b42fbca2ab]

Authors Dobson R, Miller RF, Palmer HE, Feldmann M, Thompson EJ, Thompson AJ -More
Category Primary study
JournalJournal of neuroimmunology
Year 2010
Links DOI, Pubmed
BACKGROUND: Plasma and B cells are implicated in multiple sclerosis (MS) and produce free light chains (FLC) that are excreted in urine. OBJECTIVE: To confirm that demyelinating diseases (DD) cause increased urinary FLCs. METHOD: Urinary FLC in 50 patients with DD were compared to 20 patients with posterior uveitis (PU), 19 with AIDS, 34 with rheumatoid arthritis (RA) and 19 normal controls (NC). RESULT: Subjects with DD, PU, RA and AIDS have higher urinary FLCs than NC (p<0.01). Urinary FLCs did not correlate with gadolinium-enhancing lesions on MRI. CONCLUSIONS: Urinary FLCs are raised in DD. Further studies are required to see if they correlate with disease activity.
Epistemonikos ID: bb5e73847222a71fe5d4e03948a08356ed3a9bb7
First added on: Dec 03, 2021