Global Prevention of Asthma in Children Study

INTERVENTION: House Dust Mites ‐ 7.5 mcg/0.2ml (Dermatophagoides pteronyssinus & Dermatophagoides farinae); Cat (11.3 mcg/0.2ml) and Timothy Grass (15.0 mcg/0.2ml) or matching placebo orally once daily for 12 months CONDITION: Allergic Rhinitis Asthma PRIMARY OUTCOME: To assess whether oral immunoprophylaxis reduces allergic sensitization to any of the treatment mix allergens 3 years after the end of treatment. This will be measured via a skin prick test. SECONDARY OUTCOME: To assess whether oral immunoprophylaxis reduces the incidence of asthma 3 years after completing treatment. This will be assessed by incidences of wheeze and/or doctor diagnosis INCLUSION CRITERIA: 1. Diagnosed with eczema (atopic dermatitis) 2. Family history of eczema, allergic rhinitis, or asthma 3. Allergy to one or more of the following: egg white, cow’s milk, peanut, or soybean 4. Weigh at least 8.0 kg 5. Parent or guardian willing to provide informed consent