A Randomized, Double Blind, Controlled Trial for the Effect of Yueju Pill in The Treatment of Patient with Depression

INTERVENTION: Group 1:YUEJU PILL 12g/day+placebo;Group 2:YUEJU PILL 23g/day(week1)12g/day(week2‐4)+placebo;Group 3:ESCITALOPRAM 10mg/day+placebo; CONDITION: Depression PRIMARY OUTCOME: HAMD‐24;QIDS‐16;PHQ‐9;Stagnation syndrome TCM syndrome differentiation scale;TCM constitution classification and judgment self test; INCLUSION CRITERIA: 1) Meet the diagnostic criteria for DSM‐V depression; 2) Aged 18‐75 years old; 3) Hamilton Depression Scale (24 items) score HAMD‐24 = 20 points; Montgomery Depression Rating Scale score MADRS = 12 points; 4) Chinese medicine (including Chinese herbal medicines and medicinal herbs and decoctions), Western medicine (Prozac, Lai Shi Pu, Bolexin, etc.) have not been used in the past 1 week, or in the short term (3‐5) Those who have taken the above drugs within days) have been deactivated for more than 7 days; 5) Those who are willing to accept 30 days of treatment, informed consent, and signed informed consent.