Effects of perioperative general anesthesia and vasoactive drugs on pulmonary circulation in patients with pulmonary hypertension

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Hypophysin group:After induction of anesthesia, the initial concentration of pituitary lutein was pumped to maintain, and the maximum concentration was adjusted to 0.04 U/min. The dosage was adjusted according to the patient's systemic blood pressure to maintain the systemic blood pressure above 90% of the patient's basal blood pressure. Observe the changes in pulmonary pressure.;Norepinephrine group:After induction of anesthesia, noradrenaline was administered for 4‐12ug/min maintenance, and the dosage was adjusted according to the patient's systemic blood pressure to maintain the systemic blood pressure at more than 90% of the patient's basal blood pressure. Changes in pulmonary pressure were observed.; CONDITION: Pulmonary hypertension PRIMARY OUTCOME: Mean Arterial Pressure;Pulmonary Artery Pressure;Ratio of pulmonary resistance to systemic resistance; SECONDARY OUTCOME: Urine volume;Cardiac index;Heart rate;Eccentricity Index;Blood electrolyte concentration;Partial Pressure of Oxygen;Partial Pressure of Carbon Dioxide; INCLUSION CRITERIA: 1.Age >= 18 years old; 2.ASA ? ?, Patients intending lung transplantation under general anesthesia.
Epistemonikos ID: bb1694ef08c6ff708c19a7e23b0bb65ebb55dca2
First added on: Sep 12, 2026