Exploration of the Synergistic Effect and Mechanism of Kuanxiong Aerosol Combined with Moxibustion Therapy on Cardiac Function in Patients with Coronary Heart Disease Complicated with Chronic Heart Failure Based on the Theory of "Qi-Blood Correlation"

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Combination Therapy Group:Standard therapy plus: Kuanxiong aerosol (sublingual spray, 2 puffs each time, hold for about 30 seconds before swallowing, twice daily); Acupuncture moxibustion (gentle moxibustion at Zhongwan, bilateral Xinshu, bilateral Neiguan, and Guanyuan acupoints, 15 minutes per point, 5 times per week, continuous for 8 weeks);Kuanxiong Aerosol Group:Standard therapy plus: Kuanxiong aerosol (sublingual spray, 2 puffs each time, hold for about 30 seconds before swallowing, twice daily); Sham moxibustion (using inert tools resembling moxa with similar appearance and warmth, identical procedure to real moxibustion group);Control Group:Standard therapy plus: Sham Kuanxiong aerosol (without nitroglycerin or any herbal active ingredients, identical packaging to Kuanxiong aerosol); Sham moxibustion treatment (same frequency and duration as previous); CONDITION: Coronary Heart Disease and Chronic Heart Failure PRIMARY OUTCOME: Left Ventricular Ejection Fraction (LVEF);N‐terminal pro‐B‐type Natriuretic Peptide (NT‐proBNP); SECONDARY OUTCOME: 6‐Minute Walk Distance;Minnesota Living with Heart Failure Questionnaire Score;Frequency of Angina Attacks and Nitroglycerin Use;New York Heart Association Functional Classification;Traditional Chinese Medicine Syndrome Score (symptoms related to Qi deficiency and blood stasis); INCLUSION CRITERIA: 1. It meets the diagnostic criteria for chronic heart failure caused by coronary heart disease and is classified as grade II‐III by the New York Heart Association of the United States. 2. Age: 40‐75 years old, gender not limited; 3. All subjects were informed and voluntarily signed the written informed consent form.
Epistemonikos ID: ba656bca7fd832e7830312cb731b6459e02af17b
First added on: Apr 25, 2026