The effect of nutritional supplementation on retinal function

INTERVENTION: Nutritional supplement (oral) containing vitamin C 150 mg, vitamin E 15 mg, lutein 12 mg, zeaxanthin 0.6 mg, copper 400 µg, zinc 20 mg, omega‐3 fatty acids 1,080 mg per day for 80 weeks. Control group: no interventions (no placebo used) CONDITION: Age‐related macular disease ; Eye Diseases ; Other retinal disorders PRIMARY OUTCOME: Multifocal electroretinogram amplitudes and latencies, assessed every 20 weeks for a period of 80 weeks SECONDARY OUTCOME: Macular pigment optical density, assessed every 20 weeks for a period of 80 weeks INCLUSION CRITERIA: All participants (both males and females) must be aged 18 ‐ 80 years. 1. For early age‐related maculopathy (ARM) group in either eye or both eyes: 1.1. Drusen 1.2. Drusen with hyperpigmentation 1.3. Drusen with hypopigmentation 2. For early age‐related maculopathy (ARM) group and normal group in either eye or both eyes: 2.1. Best corrected visual acuity of 6/9 or better 2.2. Good central fixation (necessary for the multifocal electroretinogram [mfERG]) 2.3. Clear optical media 2.4. No signs of other retinal or optic nerve disease 2.5. Good general health 2.6. No medication that affects the retina