A brief yoga intervention implemented during chemotherapy for colorectal cancer: A randomized controlled pilot study

BACKGROUND/PURPOSE: Fatigue and other treatmentrelated symptoms (e.g., pain, distress) are critical targets for improving quality of life in patients undergoing chemotherapy. Yoga is a promising intervention for addressing such symptoms. This study aimed to establish the feasibility of conducting a randomized controlled study of a brief yoga intervention among patients receiving chemotherapy for colorectal cancer. METHODS: We randomized adults with colorectal cancer to a brief Yoga Skills Training (YST) or an attention control (AC; empathic attention and recorded education). Both interventions consisted of three fifteenminute sessions, implemented individually while patients received chemotherapy, and recommended home practice. The primary outcome was feasibility (accrual, adherence, data collection, retention). Descriptive statistics were also assessed for self‐reported outcomes (i.e., fatigue, pain, distress) and inflammatory biomarkers to inform future studies. RESULTS: Of 52 patients initially identified, 28 were approached, and 15 enrolled (age M=57.5 years; 80%White; 60%Male). Reasons for declining participation were: not interested (n=6), did not perceive a need (n=2), and other (n = 5). Intervention adherence to in‐person sessions for both groups was 76% (intention‐to‐treat) or 97% (retained in study). Two participants were lost to follow‐up in each group due to treatment changes. Thus, 75% of participants were retained in the YST and 71% in the AC arm. Participants retained in the study completed all measures (descriptive statistics will be provided). CONCLUSIONS: This study supported the feasibility of conducting a larger randomized controlled trial to assess YST among patients receiving chemotherapy for colorectal cancer. Data collected and challenges encountered will inform future research. Research Implications: Results support the feasibility of a trial to determine if the YST effectively reduces fatigue and other treatment‐related symptoms compared to an AC. Practice Implications: It is feasible to implement the YST in the clinical setting while patients are receiving chemotherapy for colorectal cancer.