A Randomized Controlled Study of Transcranial Temporal Interference Electrical Stimulation for Consciousness Recovery in Patients with Prolonged Disorders of Consciousness and Exploration of Its Mechanisms

INTERVENTION: tTIS group (intervention group):Transcranial temporal interference stimulation (tTIS) combined with conventional treatment.;sham tTIS group (control group):sham tTIS stimulation combined with conventional treatment.; CONDITION: prolonged disorders of consciousness (pDOC) PRIMARY OUTCOME: improvement rate of the level of consciousness;The incidence of adverse events (AEs) and serious adverse events (SAEs) related to tTIS treatment.; SECONDARY OUTCOME: electroencephalography (EEG)‐related parameters;Functional magnetic resonance imaging (fMRI)‐related parameters;serum biomarkers of consciousness level;functional near‐infrared spectroscopy (fNIRS)‐related parameters;CRS‐R, GCS, FOUR, GOSE; INCLUSION CRITERIA: 1.Aged 18 to 80 years; 2.Patients clinically diagnosed as vegetative state (VS) or minimally conscious state (MCS) based on the Coma Recovery Scale‐Revised (CRS‐R) assessment. 3.Disease duration >= 28 days and < 1 year; 4.Patients with disorders of consciousness (DoC) caused by traumatic brain injury, stroke, or hypoxic encephalopathy. 5.Informed consent obtained from the patient's legal guardian.