Study Comparing Sugammadex and Neostigmine for Recovery after General Anaesthesia in Major Abdominal Surgery

INTERVENTION: Intervention1: Sugammadex: Sugammade X2 mg/kg intravenously over 10 seconds. Control Intervention1: Neostigmine: Neostigmine 0.05 mg/kg (maximum 5 mg) with glycopyrrolate 0.01 mg/kg intravenously over 10 seconds. CONDITION: Health Condition 1: K70‐K77‐ Diseases of liver Health Condition 2: K35‐K38‐ Diseases of appendi XHealth Condition 3: K40‐K46‐ Hernia Health Condition 4: K50‐K52‐ Noninfective enteritis and colitis Health Condition 5: K55‐K64‐ Other diseases of intestines Health Condition 6: K65‐K68‐ Diseases of peritoneum and retroperitoneum Health Condition 7: K90‐K95‐ Other diseases of the digestive system Health Condition 8: K20‐K31‐ Diseases of esophagus, stomach and duodenum Health Condition 9: K80‐K87‐ Disorders of gallbladder, biliary tract and pancreas Health Condition 10: N00‐N99‐ Diseases of the genitourinary system Health Condition 11: C00‐D49‐ Neoplasms Health Condition 12: A00‐A09‐ Intestinal infectious diseases PRIMARY OUTCOME: To compare the time to extubation ,TOF ratio more than or equal to 0.9 after administration of neuromuscular block reversal with sugammadex versus neostigmine in patients undergoing major abdominal surgeries under general anaesthesia with vecuronium‐induced neuromuscular blockade. ; Timepoint: To be seen at the time of extubation after administration of neuromuscular reversal agent ; SECONDARY OUTCOME: To compare neuromuscular monitoring parameters ,Train of Four count ratio at ; 1. time of reversal administration ; 2. time of extubation between the two groups. ; To compare haemodynamic variables SBP, DBP, MAP & Heart Rate at 0, 3, & 5 minutes post‐extubation following administration of reversal agents. ; To evaluate postoperative recovery quality as assessed by Modified Aldrete Recovery Score & PACU stay duration. ; To compare the incidence & nature of adverse events bradycardia, PONV, bronchospasm, desaturation, residual paralysis, & hypersensitivity between the two groups. ; Timepoint: To check DBP ,SBP , HR , MAP at 0 , 3 & 5 minutes after extubation . ; To monitor MODIFIED ALDRETE SCORE & PACU stay duration after extubation. ; ; ; INCLUSION CRITERIA: American Society of Anesthesiologists physical status Class I or II. Scheduled for elective major abdominal surgery laparotomy for bowel resection, colostomy, hepatic, splenic, or gynaecological procedures lasting more than 60 minutes, requiring general anaesthesia with tracheal intubation. Requiring neuromuscular blockade with vecuronium. Providing written, informed consent.