Acute effects of smoking and oral nicotine on blood haemostatis using thromboelastography

INTERVENTION: Randomised controlled trial: 1. Smoking a cigarette versus smoking a sham cigarette 2. Inhaling from a nicotine inhaler versus inhaler from a inhaler with no nicotine CONDITION: Haemostasis ; Haematological Disorders ; Other coagulation defects PRIMARY OUTCOME: Thromboelastography variables:; 1. R‐value; 2. K‐value; 3. Angle; 4. Maximum amplitude; 5. Coagulation index SECONDARY OUTCOME: Not provided at time of registration INCLUSION CRITERIA: Healthy adult smokers who fall into American Society of Anaesthesiologists classes 1 and 2