Adult solitary eosinophilic granuloma of the orbital vertex and paranasal sinuses: case report and review

Objective: to report a rare localization of Langerhans cell histiocytosis and to define its differential diagnosis and therapeutic options. Description: a 32 year-old male with derecasing visual acuity, headache and epistaxis. MRI: parasellar lytic lesion extending to nasal cavities. Transnasal biopsy: proliferation of S100 positive cells and eosinophilic granulocytes. Intervention: radiation therapy was followed by reission. Conclusion: Langerhans cell histiocytosis can present as a unifocal (eosinophilic granuloma) or multifocal sidorder. Usually affects children. The skull base is rarely affected. Surgery with or without radiotherapy is the treatment of choice for solitary accessible lesions. Isolated radiotherapy and intralesional steroids are valid options. Systemic disease requires chemoterapy