Clinical Outcomes of MP Persona vs. Persona Knee-PS

This is a prospective, double‐blinded, randomized control study comparing the TKA Zimmer Medial Pivot Persona design to the traditional Zimmer Persona Knee‐PS. Eighty patients requiring a TKA will be recruited and randomized to one of the two treatment arms following confirmation of eligibility criteria. Forty age and sex matched healthy participants with no knee OA will also be recruited to provide a comparator measure of "normal" joint motion. Clinical follow‐up visits and radiographic assessments will be performed pre‐ and post‐operative at 6‐weeks, 1‐year, 2‐years. Knee kinematics and self‐assessment will be completed at the following intervals: pre‐operative as baseline assessments for knee motion, 1‐year, 2‐years. Measures will include joint mechanics and neuromuscular activation during walking and stair stepping measured with motion capture and electromyography, and clinical/self assessment including pain in response to physical activity. Any other adverse events and complications (i.e, implant failure, re‐operation, infection) will be record throughout the study. Healthy participants will only be assessed once to provide normative data.