Precision Nutrition Recommendations Generated by Metataxonomic Microbiome Testing Improve Food Group Choices and Intestinal Health Indicators in an Obese Population in Colombia

The study investigated the effects of precision nutrition recommendations on gutmicrobiota diversity and metabolic health in obese adults. Fifty participants (BMI ≥30)affiliated with Comfama healthcare in Antioquia, Colombia, were randomized into anintervention group (n=25) receiving a 12‐week diet plan designed to improve microbialdiversity and metabolic health, and a control group (n=25).The intervention emphasized increased fiber intake, fermented foods, reduced sugar andsaturated fats, and a variety of colorful fruits and vegetables. Probiotic or prebioticsupplements were included in selected cases. Outcomes were measured at baseline and after12 weeks and included gut microbiota diversity via 16S rRNA gene sequencing (V3‐V4region), blood biomarkers (HbA1c, total cholesterol, HDL, LDL, triglycerides, glucose),anthropometric data, dietary adherence, physical activity, and psychological measures.Significant improvements in microbial diversity and intestinal health indicators wereobserved in the intervention group.