The effect of oxygen on diaper dermatitis in infants: A randomized controlled trial.

Considering the role of oxygen in wound care, it can be used in the management of diaper dermatitis, defined as an 'inflammatory reaction.' This study aims to investigate the effect of oxygen therapy on diaper dermatitis in infants. This study was designed as a randomized controlled trial. Infants were randomly divided into two groups: routine care group (n = 30) and oxygen therapy group (n = 30). While routine care was applied to all newborns, oxygen therapy was applied to newborns in the oxygen therapy group in addition to routine care. Oxygen therapy significantly reduced the severity of diaper dermatitis at the 24th, 48th, and 72 nd h (p < 0.05). Compared with the routine care group, the recovery rate was statistically higher in the oxygen therapy group at the 24th hour (OR 6.46 95% [2.30–18.19]), 48th (OR 5.12 95% [2.16–12.18), and 72 nd h (OR 7.98 95% [1.75–8.93]). Administering oxygen to the diaper dermatitis area reduces the severity and shortens the recovery time of diaper dermatitis. NCT05427760 (https://clinicaltrials.gov/ct2/show/NCT05427760). Registration date: April 25, 2022. • This study is the first to investigate the effect of oxygen on diaper dermatitis. Oxygen therapy can be used as an innovative method in diaper dermatitis. • Oxygen administration effectively reduces the severity of diaper dermatitis and accelerates healing. • Oxygen therapy can be used as an alternative method in the care of diaper dermatitis in infants without any side effects. • Oxygen administration can rapidly heal diaper dermatitis. It may also reduce healthcare expenses and enable quicker discharge from the hospital.