Assessment of circulating high-sensitivity c-reactive (HSCRP) as early marker for detection of diabetic nephropathy (DN)

Introduction: Inflammation plays a very important role in progression of diabetic nephropathy and lead to chronic kidney disease. Objectives: The main aim of this study is to evaluate the correlation between serum HsCRP levels with T2DM subject having high creatinine and microalbuminuria with T2DM subjects with normal creatinine and microalbuminuria. Methods: This is a scribing trial conducted at single Center at Patna city. 489 T2DM subjects in which 242 having high creatinine and microalbuminuria (Gr A) and 247 normal creatinine and microalbuminuria (Gr B) were enrolled for the study. Blood samples collected from subjects to perform HbA1C,HsCRP, creatinine and urine for microalbuminuria. Results: Both group has almost similar demographic characteristics (Avg mean duration of diabetes 10.7±3.6 and 10.1±3.2 and years, age 56±5.8 and 54±5.2 years and HbA1c 8.1±0.5 % and 7.6±0.5 % , respectively). It was observed that Hs-CRP was much higher (4.6±1.3 mg/dl) in group A (Cre 1.67±0.4, Mic Albu 82.39±9.26 mg/dl) as compared to Gr B ( HsCRP 1.1±.8, Sr. Cre 0.86±0.3, Mic Albu 12.64±9.47 mg/dl )(p value <0.001). HsCRP was also correlated to high HbA1c level (p value <0.05). Conclusion: In T2DM subjects , high serum creatinine and microalbuminuria is accompanied by elevated HS-CRP, suggesting activation of inflammatory pathways in progression of renal disease. This observation has confirmed that hsCRP can be used as early marker for detection of diabetic nephropathy.