Granulomatous hepatitis in a patient with chronic hepatitis C treated with interferon-alpha.

Authors
Category Primary study
JournalDigestive diseases and sciences
Year 1997
Common adverse effects of IFN-alpha include flulike symptoms, headache, irritability, and bone marrow suppression. Hepatic side effects are unusual except in patients with pretreatment autoimmune hepatitis. Granuloma formation in the liver as a result of IFN-alpha therapy has never been reported. We described a 48-year-old female with chronic hepatitis C infection who developed granulomatous hepatitis following treatment with IFN-alpha. The granulomatous inflammation resolved after discontinuation of IFN-alpha treatment. Possible mechanisms for this unusual occurrence are discussed.
Epistemonikos ID: b5be63aabed2c253b6af9c37b569bc6ca5aab4ba
First added on: Nov 14, 2024