Time-interference stimulation targeting cerebellar nuclei improves tremor disorders in Parkinson’s patients: a protocol for a randomized, double-blind, single-center clinical trial

INTERVENTION: Real Temporal Interference Stimulation:Active Temporal Interference Stimulation;Sham Temporal Interference Stimulation:Sham Temporal Interference Stimulation; CONDITION: Parkinson's disease; Tremor; Movement symptoms PRIMARY OUTCOME: Change from baseline in total score of Part A of the FTM‐TRS (CRST) after 19 days of treatment; SECONDARY OUTCOME: Change from baseline in MDS‐UPDRS Part III tremor items (items 3.15–3.18) following 19 days of treatment;Change from baseline in TRS tremor subscale scores at the 30‐day follow‐up after treatment completion;Change from baseline in MDS‐UPDRS Part III tremor scores (Items 3.15–3.18) at the 30‐day follow‐up; INCLUSION CRITERIA: 1.Age =50 years; 2.Diagnosed with idiopathic Parkinson's disease according to the MDS 2015 diagnostic criteria, accompanied by tremor disorder; 3.Diagnosed for at least 2 years, with stable condition and able to cooperate in research assessments and interventions; 4.The dosage of anti Parkinson's disease drugs was stable at least 4 weeks before enrollment; 5.By signing the informed consent form, I or the legal guardian can understand and be willing to participate in this study; 6.Actively cooperate with tremor assessment;