Corrigendum: "An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans".

Reports an error in "An intronic variant in OPRD I Predicts treatment outcome for opioid dependence in African-Americans" by Richard C. Crist, Toni-Kim Clarke, Alfonso Ang, Lisa M. Ambrose-Lanci, Falk W. Lohoff, Andrew J. Saxon, Walter Ling, Maureen P Hillhouse, R. Douglas Bruce, George Woody and Wade H. Berrettini (Neuropsychopharmacology, 2013[Sep], Vol 38[10], 2003-2010). In the original article, in the first paragraph of the Discussion section, the fourth sentence (at the end of the right column of page 2007) should read: 'Conversely, African-American patients with the CC genotype had significantly BETTER opioid use outcomes when treated with methadone than individuals in the combined CT and TT genotypes group.' (The following abstract of the original article appeared in record [rid]2013-30225-019[/rid]). Although buprenorphine and methadone are both effective treatments for opioid dependence, their efficacy can vary significantly among patients. Genetic differences may explain some of the variability in treatment outcome. Understanding the interactions between genetic background and pharmacotherapy may result in more informed treatment decisions. This study is a pharmacogenetic analysis of the effects of genetic variants in OPRDI, the gene encoding the (δ-opioid receptor, on the prevalence of opioid-positive urine tests in African-Americans (n = 77) or European-Americans (n = 566) undergoing treatment for opioid dependence, Patients were randomly assigned to treatment with either methadone or buprenorphine/naloxone (Suboxone) over a 24-week open-label clinical trial, in which illicit opioid use was measured by weekly urinalysis. In African-Americans, the intronic SNP rs678849 predicted treatment outcome for both medications. Methadone patients with the CC genotype were less likely to have opioid-positive urine tests than those in the combined CT and TT genotypes group (relative risk (RR) = 052, 95% confidence interval (CI) = 0.44-0 60, p = 0.001). In the buprenorphine treatment group, however, individuals with the CC genotype were more likely to have positive opioid drug screens than individuals in the combined CT and TT genotypes group (RR = 2.17, 95% CI = 1.95-2 68, p = 0008). These findings indicate that the genotype at rs678849 predicts African-American patient response to two common treatments for opioid dependence, suggesting that matching patients to treatment type based on the genotype at this locus may improve overall treatment efficacy. This observation requires confirmation in an independent population. (PsycInfo Database Record (c) 2021 APA, all rights reserved)