Effects of S-ketamine on brain activation in healthy women, healthy women prone to depression and fibromyalgia patients.

INTERVENTION: Esketamine 0.4 mg/kg or placebo will be administered intravenously in 40 minutes. CONDITION: Fibromyalgia, Depression, Ketamine , fMRI ; ; PRIMARY OUTCOME: Esketamine effects on brain activity and connectivity.; Esketamine, esnorketamine and eshydroxynorketamine plasma concentrations. SECONDARY OUTCOME: Psychological measures to assess depression and pain symptoms. ; ; Visual Analogue Scale (VAS) to assess mood, alertness and calmness (Bond and Lader). ; ; VAS to assess psychedelic effects (Bowdle). ; INCLUSION CRITERIA: Right‐handed female participants 18‐45 years old, naive to ketamine and pre‐screened using the BDI‐II (Beck Depression Inventory second edition). Group 1: healthy, no history of depression and BDI score < 5. Group 2: prone to depression: currently only sub‐clinical symptoms indicated by a BDI score ranging from 5 to 17, but previous episode (1 or 2) of clinical depression as indicated by the M.I.N.I. Group 3: pain patients diagnosed with fibromyalgia (meet the 2010 American College of Rheumatology diagnostic criteria), who also show sub‐clinical symptoms of depression as indicated by the M.I.N.I. and a BDI score ranging from 5 to 17.