Clinical randomization of an Antifibrinolytic agent in Significant Haemorrhage

INTERVENTION: Loading dose of Tranexamic acid or placebo 1 grm. in 100 ml of 0.9% NaCL over 10 min. followed by 1 grm. of tranexamic acid or placebo over 8 hrs duluted in 0.9% NaCL 240 ml CONDITION: Haemorrhage following trauma PRIMARY OUTCOME: Death in hospital within 4 weeks of injury SECONDARY OUTCOME: Receipt of a blood products transfusion, the number of units of blood products transfused, surgical intervention & the occurrence of thrombo‐ embolic episodes INCLUSION CRITERIA: All patients whose age is 16 yrs old or above with significant haemorrhage following trauma.( systolic blood pressure 90 mm hg and / or heart rate is more than 110/ min.) within 8 hours of injury