Preemptive administration of dexamethascone and diclofena: sodium - comparate study of analgesic and anti-inflam´matory effetiveness

The concept of preemptive analgesia has been studied with the purpose of reducing or prevent the production of chemical mediators such as histamine, serotonin, prostaglandins, and others directed related with algic and inflammatory processes. Fifty Four patients participated of the study, 19 male and 35 female with ages between 16 to 65 years old, ali of them with not unerupted or sem i unerupted third molar removal, met at specialization course in surgery and traumatology maxillofacial of Fundação para o Desenvolvimento Científico e Tecnológico da Odontologia (FUNDECTO). In double blind method, the patients received,randomly, one hour before the surgery an unique oral dose of diclofenac sodic 50 mg or dexamethasone 8 mg or placebo. The surgeries were performed with standard procedure of asepsis and using conventional anesthetic technique and standardized surgical technical by the FUNDECTO'S specialization course. The patients were oriented in a way that, after post surgical intense pain, utilized as analgesic medication support (paracetamol 650mg AP) in unique dos age of 1300mg (2 tablets), after at least one hour after the beginning of the surgery. The pain intensity was registered in a analog scale in the postoperative of 1 h,2h, 3h, 6h, 8h, 12h, 24h and 48h and the edema registered in a scale on the first, second, fourth and seventh days after the surgery. The data were submitted to the non parametric test of variance analysis in a factor of Kruskal-Wallis. The results showed that the dexamethasone group presented average scores of pain during the whole period rated inferior to the diclofenac sodic group and placebo group with a significant difference between them. Related to the edema, the average scores during the whole rated process showed significant statics between the dexamethasone group and the placebo group. The comparative analysis for pain intensity between the groups in each rated time...