A Relation Between Craving Induction and Treatment Response in Deep Transcranial Magnetic Stimulation (dTMS) for Reducing Antipsychotic-induced Weight Gain in Schizophrenia

The underlying causes of antipsychotic‐induced weight gain are still unknown. Someresearch point out that it has something to do with metabolic disturbances and changes inappetite and food intake. With fMRI study, it is reported having dysfunction betweenprefrontal and insula cortex of its cognitive regulation, interoceptive signals andreward control. dTMS, H4 coil in particular, simultaneously targets prefrontal and insulacortex. Previous study has been deconstrued that dTMS could significantly improve weightgain. Moreover, it is reckoned that TMS has state‐dependent effects on brain circuitry,suspected that symptom provocation may be made it more susceptible to modulation whichmay improve response. Therefore, this study is to explore the efficacy of dTMS onantipsychotic‐induced appetite, and whether provoking symptoms can improve dTMS clinicalresponses.With regard to investigate this, the investigators will be carried out a randomizedsingle session dTMS, crossover, sham controlled clinical trial. 30 Patients withschizophrenia will be randomly treated with dTMS after food cue induced craving (FCC),dTMS without FCC and sham condition without FCC. Each session has three days intervalsfor washout. The follow‐ups are at the baseline and after each session immediately. Themain outcome measures include the change in Food‐Cravings Questionnaires state (FCQ‐S)score, Visual Analogue Scale (VAS) score, changes in Stop‐Signal test (SST) behavioralassessment and the resting‐state functional magnetic resonance imaging data.