Effect of Recombinant Human Brain Natriuretic Peptide on Coronary Microvascular Function in Patients Undergoing Coronary Artery Rotational Atherectomy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

INTERVENTION: Experimental group:Intravenous infusion of recombinant human brain natriuretic peptide;Control group:Intravenous infusion of saline solution; CONDITION: Coronary microcirculation disorder PRIMARY OUTCOME: Preoperative Angio‐IMR;Postoperative Angio‐IMR; SECONDARY OUTCOME: The rate of major adverse cardiovascular events (MACE) 1 year after the surgery;Cardiac injury biomarkers;NT‐proBNP;intravascular ultrasound(IVUS) indicators; INCLUSION CRITERIA: 1.Age: 18 ‐ 80 years old; 2. Patients with severe coronary artery calcification who successfully undergoes rotational atherectomy during percutaneous coronary intervention (PCI); 3.The angiography images have good quality and can enable the Angio‐IMR test to be conducted. 4. Obtain informed consent;