Efficacy and safety of different formulations of Lactobacillus reuteri in eradication of helicobacter pylori

INTERVENTION: Intervention1: PROBIOTIC: Group A Probiotic formulation A with zinc carnosine for 14 days Heat killed Lactobacillus reuteri 10 billion cells with zinc L carnosine providing 8.5 mg elemental zinc twice daily followed by probiotic only for the next 14 days Group B Probiotic formulation B with zinc carnosine for 14 days Live Lactobacillus reuteri 100 million CFU with zinc L carnosine providing 8.5 mg elemental zinc twice daily followed by probiotic only for the next 14 days Control Intervention1: PLACEBO: similar looking placebo for 28 days CONDITION: Health Condition 1: K30‐ Functional dyspepsia PRIMARY OUTCOME: H pylori eradication rate assessed by stool antigen test at 4 weeks post‐eradication phase with Bismuth Quadruple therapy 6 weeks after enrolmentTimepoint: 6 weeks SECONDARY OUTCOME: Incidence and severity of antibiotic‐associated side effects ; Effect on Gastrointestinal symptoms ; Changes in gut microbiota composition at baseline 4 weeks and 8 weeks ; Patient compliance and adherence rates ; Gastric microbiota analysis at baseline and at 8 weeks ; Timepoint: 4 weeks and 8 weeks INCLUSION CRITERIA: Adults of both sexes 18 to 65 years Confirmed H pylori infection via stool antigen test or histopathology Treatment naive Known allergy to Penicillin Willingness to comply with study protocol and follow up visits