Influence of febuxostat and allopurinol on renal function for hyperuricemia

INTERVENTION: Febuxostat group: The patients was treated by 10 mg/day of febuxostat and controlled Uric acid less than 6mg/dl/ (maximum 60 mg/day of febuxostat) Allopurinol group: The patients was treated by 100 mg/day of allopurinol and controlled Uric acid less than 6mg/dl/ (maximum 300 mg/day of febuxostat) CONDITION: Hyperuricemic patients (Uric acid>8.0mg/dL) PRIMARY OUTCOME: 1) Serum uric acid; 2) Urinary Albumin SECONDARY OUTCOME: 1) serum Cr; 2) eGFR; 3) cystatin C; 4) Oxidized LDL; 5) T‐cho, TG, LDL,HDL; 6)PWV; 7)BNP, EF, LVM; 8) side effects INCLUSION CRITERIA: Serum Uric acid>8.0mg/dl Patients from whom informed consent was obtained