Comparison of the effects of Dexamethasone and Non-Steroidal Anti-inflammatories in the post-operative Removal of wisdom teeth

INTERVENTION: This study is a randomized, 3‐arm, triple‐blind clinical trial. 29 patients and 36 teeth were selected (taking into account that each patient could have two teeth allocated to two different groups) who were divided into three experimental groups: 1 ‐ DE X(patients who underwent third molar extraction and received dexamethasone 4mg every 12 hours for three days). 2 ‐ IBU (patients undergoing third molar extraction who received ibuprofen 400mg every 8 hours for three days). 3 ‐ CETO (patients undergoing third molar extraction who received 10mg sublingual ketoprofen every 8 hours for three days). The teeth were randomly allocated using the envelope method. The patient, surgeon and data evaluator were duly blinded. After removal of the impacted third molars, the patients underwent evaluation of the primary outcome, which included analgesia (visual analog scale and number of rescue analgesics consumed) and the secondary outcome, which included postoperative edema and trismus. Patients were followed up for 7 days. CONDITION: Anti‐Inflammatory Agents; Adrenal Corte XHormones E03.091 PRIMARY OUTCOME: Expected outcome 1: It was hoped that the use of dexamethasone would promote lower or equal values to the non‐steroidal anti‐inflammatory drugs Ibuprofen and Ketorolac, with regard to the parameters of pain. Outcomes found 1: As an outcome, it was observed that the ketorolac was the one that promoted the best values for the parameters of analgesia SECONDARY OUTCOME: Expected outcome 2: It was expected to observe that the use of dexamethasone could promote lower or equal values to the non‐steroidal anti‐inflammatory drugs Ibuprofen and Ketorolac, regarding the parameters edema and trismus Outcome found 2: As a secondary outcome, it was observed that the NSAID ketorolac was the one that promoted better values for the parameters edema and trismus INCLUSION CRITERIA: They presented good systemic health conditions (ASA I); were between 18 and 35 years of age of both sexes; were indicated for extraction of the 38 and/or 48 impacted or semi‐impacted dental elements, requiring a total mucoperiosteal flap and osteotomy