An open randomized controlled study of topical timolol maleate gel for the treatment of infant hemangioma: comparison of safety and efficacy between topical timolol maleate gel and dye laser

INTERVENTION: Small amount of 0.5% timolol maleate gel is applied to tumor two times a day for 6 months. The current standard dye laser treatment for infant hemangioma in Japan (aggressive irradiation treatment only for proliferative phase of the tumor) CONDITION: Infant hemangioma PRIMARY OUTCOME: Size and color of tumor.; We evaluate the short‐term efficacy and safety with Photo‐finish every month. SECONDARY OUTCOME: Condition of the affected skin.; We check skin complications of the external medication every month. INCLUSION CRITERIA: Superficial infant hemangioma of less than 40 mm in diameter that is located in limbs or truncus.