A randomized, double-masked, placebo-controlled study of the use of misoprostol versus placebo for diagnostic hysteroscopy in postmenopausal women

Hysteroscopy is one of the most useful procedure to study uterine cavity and widely used in gynecologic clinic. Although many controlled clinical trials have shown advantages in the use of misoprostol in realeasing cérvix uterine resistanse, there are few evidence regarding its use before office hysteroscopy in postmenopausal women. OBJECTIVE: to compare the trans and postoperative results of postmenopausal women underwent office hysteroscopy without anesthesia that used misoprostol or placebo previouslly to the procedure to mature the uterine cérvix in two teaching hospitals in Recife. PATIENTS AND METHODS: a randomized, double masked, clinical trial was conducted enrolling 120 postmenopausal women who had been submitted to office hysteroscopy without anesthesia at IMIP and Barão de Lucena teaching hospital. Among those patients 60 were randomized allocated in the study group using 200µg of vaginal misoprostol and 60 took part in the placebo group using 200µg of a vaginal placebo.The following variable were studied: duration of the procedure, frequency and intensity of pain during the exame, necessity of additional dilatation, side effect as (genital bleeding, nauseas, vomits, diarrhea, and hyperthermia) and complications (uterine perforation, false way, cervical laceration, infections and pain in the imediate postoperatory period). For analysis statistics we used the tests of association qui-square, accurate test of Fisher and Mann-Whitney for comparison of the groups, considering itself significant with lesser alpha error that 5 por cento. RESULTS: We found no significant statistic difference between the...