Comparing the effect of honey mouthwash with hydrogen peroxide mouthwash on oral lesions healing in patients with Pemphigus

INTERVENTION: Control group: H2O2 mouthwash 1.5%, daily, half an hour after each meal Intervention 1: Intervention group: honey mouthwash 12.5%, daily, half an hour after each meal. Intervention 2: Control group: H2O2 mouthwash 1.5%, daily, half an hour after each meal. Intervention group: honey mouthwash 12.5%, daily, half an hour after each meal Treatment ‐ Other CONDITION: oral lesions in pemphigus. ; Pemphigus Pemphigus PRIMARY OUTCOME: Grade of oral lesions. Timepoint: at the begining and then every other day for ten days. Method of measurement: Oral Mucositis Visual Assessment Guide of WHO. SECONDARY OUTCOME: Healing erythema. Timepoint: every other day/and till 10 day. Method of measurement: Oral Mucositis Visual Assessment Guide of WHO. Improvement patient’s dietary intake. Timepoint: every other day/and till 10 day. Method of measurement: Oral Mucositis Visual Assessment Guide of WHO. Reducing pain in oral lesions. Timepoint: every other day/and till 10 day. Method of measurement: visual analog scale of pain intensity. INCLUSION CRITERIA: INCLUSION CRITERIA: patients with oral pemphigus lesions (grades of 1‐3 were considered as oral ulcers), treated with classical pemphigus (a corticosteroid and immunosuppressive). Exclusion criteria: any broad spectrum antibiotics in the patient medication instructions, underlying disease (diabetes, infections, mouth and teeth), history of allergy to honey, history of chemotherapy and radiation therapy for head and neck and lesions worsening during using honey mouthwash (in this case, treatment will be returned to the routine).