Glucosamine Hydrochloride combined with Hyaluronate Sodium for Temporomandibular Joint Disorders: a Randomized Controlled Trial

INTERVENTION: Group A:Intra‐articular injection of sodium hyaluronate into the upper and lower camber of TMJ, once every week, for four weeks. Taking glucosamine hydrochloride (240mg), two pills each time, three times a day, for three months;Group B:Intra‐articular injection of sodium hyaluronate into the upper and lower camber of TMJ, once every week, for four weeks. Taking placebo (no active component), two pills each time, three times a day, for three months; CONDITION: M13.885 temporomandibular joint disorders(osteoarthritis type) PRIMARY OUTCOME: clinical sign;synthesised variables;concentration of IL‐6 in the articular fluid;cone beam CT variables;participants assessed variable; SECONDARY OUTCOME: economic evaluation variables;quality of life; INCLUSION CRITERIA: 1. Males or females of 16 70 years old; 2. Be diagnosted as temporomandibular disorders (osteoarthritis type) both clinically and radiographically; 3. The participants who consent to participant in.