Efficacy of a Single dose versus Triple Dose Regimen of Mebendazole against Hookworm infections among School Children: Randomized trial.

INTERVENTION: mebendazole drug CONDITION: ; Hookworm infection Hookworm infection PRIMARY OUTCOME: Cure rate or CR. CR means the proportion of individual hosts positive for parasites who become parasitologically negative after treatment SECONDARY OUTCOME: Arithmetic mean of Feacal Egg Reduction Rate OR ERR. ERR is the arithmetic mean egg count at baseline of the treatment group minus mean egg count at the end of treatment period divided by the mean egg count at the baseline and express it in percent. INCLUSION CRITERIA: • Written informed consent signed by parents and/or legal guardians; and a verbal assent (children <18 years) according to Ethiopian regulation. • Able and willing to be examined by a study physician at the beginning of the study. • Able and willing to provide required stool samples at the beginning (baseline) and two to three weeks after treatment (follow‐up). • Positive for hookworm eggs in the stool. • No recent anthelminthic treatment (within past 4 weeks). • Negative pregnancy test (girls =12 years) • Apparently health individual; based on medical history, physical examination, vital signs, hemoglobin level were included • Children who were able to chew the drug were subjected for randomization • Participant had hemoglobin level above 8g/dl