A comparative evaluation of the effect of sub-gingival irrigation with ibuprofen 2% mouthwash in treatment of periodontal diseases.

INTERVENTION: Ibuprofen 2% mouthwash (made from the Faculty of Pharmaceutical Sciences, Islamic Azad University, Tehran) Intervention 1: Ibuprofen 2% mouthwash (made from the Faculty of Pharmaceutical Sciences, Islamic Azad University, Tehran). Intervention 2: Placebo Mouthwash (Made by the Faculty of Pharmaceutical Sciences, Islamic Azad University of Tehran). Placebo Mouthwash (Made by the Faculty of Pharmaceutical Sciences, Islamic Azad University of Tehran) Treatment ‐ Drugs CONDITION: Periodontal disesaes Periodontal disesaes. ; Periodontal disesaes PRIMARY OUTCOME: Clinical attachment level. Timepoint: 15 Days. Method of measurement: Periodontal probe. Pocket depth. Timepoint: 15 Days. Method of measurement: Periodontal pobe. SECONDARY OUTCOME: Reduction of bleeding on probing. Timepoint: 3 Months. Method of measurement: Periodontal probe. Reduction of Plaque Index. Timepoint: 3 Months. Method of measurement: Loe & Silness Index. INCLUSION CRITERIA: INCLUSION CRITERIA: The patients systemically healthy were selected for the study. The subjects had with periodontal pocket depths of more than 4 mm on at least two teeth in mandibular molar area that observed on probing. Exclusion Criteria: Existing systemic disease; Hypersensitive to Ibuprofen; The use of any Antibiotic or Anti‐inflammatory drugs within the 6 months preceding the beginning of the study; Cancer; Pregnant or nursing females; Smoking; Orthodontic treatments; Extensive dental restorations; Use removal denture; Mouth rinses; during the entire period of the study.