Ozone Therapy in the Treatment of Digital Ulcers in Patients With Systemic Sclerosis

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2016
Digital ulcers (DUs) in scleroderma result from recurrent Raynaud\'s phenomenon (RP) and microtrauma with high impact on quality of life, management of DUs is a great challenge for clinicians. Medical use of ozone (triatomic oxygen) was initiated in the 19th century. Ozone has multiple therapeutic effects in wound healing due to the property of releasing nascent oxygen, which has been shown to stimulate antioxidant enzymes.
Epistemonikos ID: ad0261fe428ebd2af28da853f67b1b8755fd2794
First added on: May 12, 2024