Evaluation of Safety and Efficacy of Mersina, An Ayurvedic formulation: a double blind, placebo controlled study in type 2 diabetic patients with Secondary failure to Oral drugs

INTERVENTION: Intervention1: Mersina (Antidiabetic Ayurvedic formulation): 3 g/day, 3 months Control Intervention1: CORN STARCH: 3g /day, 3 months CONDITION: Type 2 diabetic patients with secondary failure ot Oral Hypoglycemic agents PRIMARY OUTCOME: Antidiabetic activity‐‐‐‐‐‐Timepoint: 3 months SECONDARY OUTCOME: Improvement in metabolic, insulin level, HbA1c level, kidney and lipid profile‐‐‐‐‐‐Timepoint: 3 months INCLUSION CRITERIA: Secondary failure to Oral Hypoglycemic Agents was diagnosed if the patient had HbA1c levels > 8.5% even after supplementation of maximal dose of a combination of a sulphonylurea (15 mg glybenclamide or 160 mg gliclazide or 15 mg glipizide) and metformin 1500 mg/day.