Feasibility study of weekly paclitaxelin patients with pre-treatment (2 regimen) advanced / recurrent gastric cancer

Authors
Category Primary study
Year 2007
INTERVENTION: Premedication: Dexamethazon 20mg should be administered 30 minutes before Paclitaxel therapy Paclitaxel is administered on day 1, 8, and day 15 in one course of 28 days. It will be repeated until treatment stop. CONDITION: Advanced / Recurrent gastric cancer. PRIMARY OUTCOME: feasibility of the treatment (ratio of completion) SECONDARY OUTCOME: Incidence of adverse events, Response Rate,Time to treatment failure,Progression free survival, Overall survival INCLUSION CRITERIA: 1. histologically proven gastric carcinoma 2. patients who received TS‐1 or CPT‐11 as a prior chemotherapy and enough treatment free period (TS‐1: 2weeks, CPT‐11: 2weeks) 3. with measurable lesions 4. age: 20<= years old 5. PS(ECOG): 0 – 2 6. without any other severe diseases WBC 3,000<= Neutrocyte 1,500mm3<= Hemoglobin 9.0 g.dl <= Platelet 100,000/mm3 <= Total bilirubin 1.5 mg/dl => AST, ALT within five times of normal range in each institute Serum creatinin 1.5 mg/dl >= ECG normal range 7. expected survival period: longer than 3 months 8. written informed consents
Epistemonikos ID: abac1088acd688642c0b3b47005b87782939484f
First added on: Aug 21, 2024