Efficacy of Ex-situ Normothermic Perfusion Versus Cold Storage in the Transplant With Steatotic Liver Graft

This is a prospective, randomized, controlled clinical trial comparing static cold storage (SCS) versus normothermic machine perfusion (NMP) for organ preservation before liver transplantation with steatotic livers (between 30 % and 60% of histologic macrovesicular steatosis), in order to: Main Objective: To compare the effect of NMP versus SCS in preventing preservation injury and graft dysfunction, as measured by highest transaminase levels during the first week after liver transplantation. Secondary Objectives: ‐ To compare graft and patient survival between the NMP and SCS steatotic livers. ‐ To compare the liver biochemical function between the NMP and SCS steatotic livers. ‐ To compare the physiological response to the reperfusion between the NMP and SCS steatotic livers. ‐ To compare the evidence of reperfusion injury between the NMP and SCS steatotic livers. ‐ To compare the evidence of ischemic cholangiopathy between the NMP and SCS steatotic livers.