Stereotactic Body Radiation Therapy With REGN2810 and/or Ipilimumab Before Surgery in Treating Participants With Progressive Advanced or Oligometastatic Prostate Cancer

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2018
PRIMARY OBJECTIVES: I. To determine the safety and tolerability for an established effective dose of systemic REGN2810 and intraprostatic ipilimumab with stereotactic body radiation therapy (SBRT) in patients with locally advanced prostate cancer with or without oligometastatic disease. SECONDARY OBJECTIVES: I. To determine overall pathologic response rate after radical prostatectomy. II. To determine prostate‐specific antigen (PSA) progression free survival in men treated with REGN2810 and intraprostatic ipilimumab with SBRT. III. To determine radiographic progression free survival in men treated with REGN2810 and intraprostatic ipilimumab with SBRT. IV. Acute and chronic adverse events (AEs).
Epistemonikos ID: ab505b204a11eb0f3010d8150c326caa2ce55093
First added on: May 21, 2024