Pain reduction in PD patients with depression: double blind, randomized clinical trial of duloxetine

INTERVENTION: the treatment groups consist of an active treatment arm (40mg/day Duloxetine) and a placebo arm. During the Titration Period (2 weeks), all subjects will be started on 1 capsule (10mg or placebo). During the Maintenance Period (10 weeks), subjects will take 2 capsules. Subjects who are unable to increase their dose can stay at 1 capsule. CONDITION: d010300 Parkinson's disease PRIMARY OUTCOME: visual analogue scale SECONDARY OUTCOME: the short‐form McGill Pain Questionnaire, Beck's Depression Scale, Parkinson's Disease Questionnaire‐39, Unified Parkinson's Disease Rating Scale, Up and Go Test INCLUSION CRITERIA: ‐ Male or Female, 20 years old or older ‐ Diagnosed with Parkinson's disease ‐ Having pain associated with PD and depression. ‐Provide written informed consent signed by the subject CNO ‐ CN‐01974679